Modalert affects various neurotransmitters involved in wakefulness and cognitive information processing. For example, systemic administration of Modalert induces a decrease in GABAergic tone and an increase in glutamate levels in the medial preoptic area.
Similarly, Modalert 200mg Tablet increases electrical coupling among cortical interneurons, thalamic reticular neurons and subcoerulear nucleus (Beck et al., 2008). These effects are not mediated by changes in cholinergic transmission.
Reduces Excessive Sleepiness
In the United States, an estimated 20% of adults experience excessive sleepiness despite a good night's rest. This condition is associated with a significant reduction in health-related quality of life and may lead to accidents, reduced work efficiency and an increased risk of disease (Pagel 2009).
The underlying cause of excess daytime sleepiness is varied, ranging from primary disorders of alertness such as narcolepsy and idiopathic hypersomnia to general medical conditions such as diabetes, depression and Parkinson's disease.
Modalert is a central nervous system stimulant that improves wakefulness, reduces depression and enhances cognitive function by changing the amount of natural substances in the area of the brain that controls sleep and wakefulness. This medication is believed to work by increasing the activity of adenosine, decreasing the activities of VLPO and ascending cholinergic tone in this area of the brain.
The effectiveness of Modafinil Australia for the treatment of shift-work sleep disorder has been demonstrated in a three-month, randomized, double-blind placebo-controlled study. This study enrolled 11 participants who were placed in either a placebo group or a modafinil group and who were assessed for both mood and cognition/psychomotor performance in a 23-day residential laboratory experiment with simulated shift work and sleep disruptions.
The primary efficacy variable was the investigator-rated Clinical Global Impression of Change for sleepiness at the final visit. Patients also completed daily electronic diaries and performed the Psychomotor Vigilance Test at night to assess their level of alertness. Additionally, the average latency to sleep onset was measured at night using the Multiple Sleep Latency Test.
Increases Alertness
Fatigue is one of the major problems in a combat environment. It is caused by various factors, such as extended duty periods, irregular work hours, circadian disruption, and stress. To mitigate combat fatigue, pharmacological countermeasures are being investigated. Psychostimulants, such as amphetamine and caffeine, have alertness-enhancing effects and can improve psychomotor activities. However, they also cause several side effects, such as stomach pain, excitation, tremor, dry mouth, and jitteriness.
Modalert, on the other hand, has fewer adverse effects. It has a longer duration of action and is less stimulating than amphetamine. Moreover, it is safer than caffeine for those with cardiovascular diseases. It also increases resting heart rate and blood pressure but does not cause excessive peripheral autonomic activation. This makes it a suitable medication for combat fatigue.